Bangalore Fertility Center Overcomes Dual Infertility Challenges for Young Couple

Bangalore: After five years of attempting to conceive, a young couple found success at a fertility clinic in the city through a tailored treatment approach addressing both partners' reproductive challenges.

The woman, aged 29, had maintained regular menstrual cycles despite being diagnosed with low ovarian reserve—a condition characterized by reduced egg quantity and quality. Her Anti-Müllerian Hormone (AMH) level measured 1.12, a marker indicating remaining egg count. Clinical research across India suggests that 30–40% of women may face this condition, with studies from JIPMER (Jawaharlal Institute of Postgraduate Medical Education & Research) finding that 40% of infertile women under 35 present with poor ovarian reserve.

Her husband, 35, carried a diagnosis of asthenoteratozoospermia, involving both reduced sperm motility and abnormal morphology. His DNA Fragmentation Index (DFI) initially registered at approximately 32%, indicating significant sperm DNA damage.

Prior to seeking treatment at Milann Fertility Hospital in Bengaluru, the couple had endured four unsuccessful intrauterine insemination (IUI) cycles and one failed in vitro fertilization (IVF) attempt elsewhere. Their previous IVF cycle produced well-graded embryos but resulted in failed implantation due to asynchronous follicular response.

The hospital's embryologist, Ms Vidyashree M C, directed a comprehensive strategy targeting both reproductive issues. The husband underwent andrological evaluation and commenced treatment, which reduced his DFI from 32% to 21%. The wife received supplementation including folic acid, CoQ10, and Vitamin D, followed by oral contraceptive pretreatment to synchronize follicle development before proceeding with IVF using an antagonist protocol—a stimulation method preventing premature ovulation.

By day three of stimulation, her Antral Follicle Count reached 15, exceeding initial expectations. Following injections of recombinant FSH and HMG hormones, the cycle yielded 14 oocytes, of which 12 matured and 10 fertilized successfully. Ten high-quality blastocysts developed by day five.

For the frozen embryo transfer cycle, clinicians employed a gentle stimulation approach combined with intrauterine platelet-rich plasma (PRP) installation—an innovative technique utilizing the patient's own blood components to enhance uterine receptivity. Endometrial thickness achieved an optimal 9 mm. A single top-grade blastocyst transfer resulted in a positive pregnancy, culminating in delivery of a healthy daughter at 38 weeks gestation.

Ms Vidyashree explained the significance of their approach: "This case demonstrates how individualized treatment protocols, addressing male-factor complications, utilizing advanced embryo culture, and implementing endometrial optimization strategies such as PRP can substantially enhance outcomes for couples contending with reduced ovarian reserve and sperm abnormalities."

The couple expressed their gratitude, stating that the hospital's comprehensive evaluation and customized treatment plan guided them through their fertility journey to successful delivery. The fertility center emphasizes its commitment not merely to achieving conception but ensuring healthy full-term pregnancies.